What causes acquired protein C deficiency?

Updated: Jan 04, 2019
  • Author: Shamudheen Rafiyath, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Causes of acquired protein C deficiency include the following:

  • Acute thrombosis
  • Warfarin therapy
  • Liver disease (eg, liver fibrosis from chronic hepatitis C [53]
  • Vitamin K deficiency
  • Sepsis
  • Certain chemotherapeutic agents (eg, L-asparaginase)
  • Uremia - Uremic patients may have a normal levels of protein C with low levels of protein C anticoagulant activity due to a antibodies against protein C [56]

Cases of acquired protein C deficiency in association with the development of a protein C autoantibody [57] and hematopoietic stem cell transplantation [58] have also been reported.

A severe form of acquired protein C deficiency associated with purpura fulminans may be observed in patients with meningococcemia and other causes of severe sepsis. [59]

Causes of increased protein C include the following:

  • Nephrotic syndrome [60]
  • Hyperlipidemia [61]
  • Normal aging

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