Which clinical history findings are characteristic of VTE in protein C deficiency?

Updated: Jan 04, 2019
  • Author: Shamudheen Rafiyath, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

The most common sites of VTE are the deep veins of the leg (DVT), mesenteric veins, and pulmonary veins. Other sites, including cerebral veins, portal veins, superficial veins, or other unusual sites are also reported. [54, 55]

In patients who present with VTE or warfarin-induced skin necrosis, family history is the best predictor for congenital thrombophilia. The initial episode of VTE in individuals with protein C deficiency is apparently spontaneous in approximately two-thirds of cases, and the other third usually have typical risk factors such as pregnancy, oral contraceptives, surgery, or trauma. Among patients with a positive family history, the risk is as high as 75% in those with severely affected families and closer to 30% in members of other families. [55]


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