Which clinical history findings are characteristic of protein C deficiency?

Updated: Jan 04, 2019
  • Author: Shamudheen Rafiyath, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

Individuals with hereditary protein C deficiency can present with venous thromboembolism (VTE), warfarin-induced skin necrosis in adults, and neonatal purpura fulminans in newborns who are homozygous or compound heterozygous for protein C mutation. Obtaining a detailed history that focuses on personal history—including previous history of thrombosis and any abnormal laboratory results—fmailiy history, and obstetric history is paramount.


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