What is the morbidity associated with peripheral arterial disease in protein C deficiency?

Updated: Jan 04, 2019
  • Author: Shamudheen Rafiyath, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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In a study of 106 patients with peripheral arterial disease (PAD) and 44 with abdominal aortic aneurysm (AAA), Komai and colleagues found that the incidences of protein C deficiency was 4.7% in patients with PAD and 4.% in patients with AAA — higher rates than those observed in the general population. Protein C activity levels were significantly lower in PAD patients with critical limb ischemia than in those with intermittent claudication. In multivariate logistic regression analysis, lower protein C activity and female gender were determinant factors of critical limb ischemia. [44]

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