What is the effect of protein C deficiency on pregnancy outcome?

Updated: Jan 04, 2019
  • Author: Shamudheen Rafiyath, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Protein C deficiency may be weakly associated with late and recurrent pregnancy loss. In the European Prospective Cohort on Thrombophilia, the odds ratio (OR) for stillbirth (defined as pregnancy loss at > 28 weeks' gestation) among women with an inherited thrombophilia was 3.6 (95% confidence interval [CI] 1.4-9.4), whereas the risk of miscarriage before 28 weeks' gestation in this cohort was not significantly different than that of nonthrombophilic women. [33] Among the subgroup of thrombophilia subjects with congenital protein C deficiency, the OR of stillbirth was 2.3 (95% CI 0.6-8.3). [34, 33] In a meta-analysis of 633 subjects with hereditary protein C deficiency, the association with recurrent fetal loss was likewise nonsignificant (OR 1.57; 95% CI 0.23-10.54). [35]

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