What is the morbidity associated with protein C deficiency?

Updated: Jan 04, 2019
  • Author: Shamudheen Rafiyath, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Clinical manifestations of heterozygous protein C deficiency include VTE and warfarin-induced skin necrosis (WISN). Whether the risk of pregnancy loss is increased in this disorder is controversial. Heterozygous protein C deficiency does not appear to be associated with an elevated risk of arterial thrombosis.

Homozygous and compound heterozygous protein C deficiency are classically associated with neonatal purpura fulminans (NPF); intracranial thromboembolism may also occur in neonates. [19] Occasionally, patients present with VTE in childhood or adolescence.

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