What is the prevalence of protein C deficiency?

Updated: Jan 04, 2019
  • Author: Shamudheen Rafiyath, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Answer

Studies in cohorts with no clinical history of venous thromboembolism (VTE) have found protein C deficiency in 1 in 200 to 1 in 500 persons. [14, 15]  In patients presenting with VTE, approximately 3-5% may have protein C deficiency. [16, 17, 18] Severe homozygous or compound heterozygous protein C deficiency occurs in approximately 1 in 500,000 to 1 in 750,000 live births. [14, 15, 16, 17, 18]


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