What is protein C deficiency?

Updated: Jan 04, 2019
  • Author: Shamudheen Rafiyath, MD; Chief Editor: Perumal Thiagarajan, MD  more...
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Protein C deficiency is a congenital or acquired condition that leads to increased risk for thrombosis. Congenital protein C deficiency is one of several inherited thrombophilias, which are a heterogeneous group of genetic disorders associated with an elevated risk of venous thromboembolism. [1] Other inherited thrombophilias include the following:

See also Hereditary and Acquired Hypercoagulability.

This article focuses on the pathophysiology, prevalence, clinical manifestations, diagnosis, and treatment of hereditary protein C deficiency. Causes of acquired protein C deficiency are also addressed.

For patient education information, see the Deep Vein Thrombosis Health Center, as well as Pulmonary Embolism.

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