What is the role of intravenous immunoglobulin (IVIG) in the treatment of necrotizing fasciitis?

Updated: Sep 02, 2020
  • Author: Steven A Schulz, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Successful use of intravenous immunoglobulin (IVIG) has been reported in the treatment of streptococcal toxic shock syndrome (STSS). [98, 99] In a multicenter, randomized, double-blind, placebo-controlled trial of the efficacy and safety of high-dose polyspecific IVIG as adjunctive therapy in 21 patients with soft-tissue STSS, mortality at 28 days was 3.6-fold higher in the placebo group. [100]

Norrby-Teglund et al successfully used high-dose polyspecific IVIG, along with antimicrobials and a conservative surgical approach, in 7 patients with severe group A streptococcal soft tissue infections. [101] However, Sarani et al indicate that this therapy has not been approved by the FDA for the treatment of necrotizing fasciitis. [102]

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