How and when should antibiotics be administered for the treatment of necrotizing fasciitis?

Updated: Oct 17, 2018
  • Author: Steven A Schulz, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Empiric antibiotics should be started immediately. Initial antimicrobial therapy should be broad-based, to cover aerobic gram-positive and gram-negative organisms and anaerobes. A foul smell in the lesion strongly suggests the presence of anaerobic organisms. The maximum doses of the antibiotics should be used, with consideration of the patient's weight and liver and renal status.


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