How much does liver cirrhosis increase the risk for necrotizing fasciitis?

Updated: Sep 02, 2020
  • Author: Steven A Schulz, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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A study by Hung et al suggested that liver cirrhosis is an independent risk factor for necrotizing fasciitis. In a retrospective analysis of hospital data, the investigators determined the incidence of necrotizing fasciitis development in 40,802 patients with cirrhosis and 40,865 control patients, over a three-year follow-up period after each patient’s initial hospitalization. Necrotizing fasciitis occurred during follow-up in 299 patients with cirrhosis (0.7%) and in 160 control patients (0.4%), giving patients with cirrhosis a hazard ratio of 1.98 for necrotizing fasciitis. It was also found that the risk of necrotizing fasciitis was greater in patients with complicated cirrhosis than in those with the noncomplicated type (hazard ratio 1.32). [43]

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