What is included in the workup of pernicious anemia?

Updated: Feb 18, 2019
  • Author: Srikanth Nagalla, MD, MS, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The workup for pernicious anemia may include the following:

  • Peripheral blood smear
  • Indirect bilirubin and lactate dehydrogenase assays
  • Evaluation of gastric secretions
  • Serum cobalamin, folic acid, methylmalonic acid, and homocysteine assays
  • Schilling test (no longer available in most medical centers)
  • A clinical trial of vitamin B12
  • Bone marrow aspiration and biopsy

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