What are the Portland Protocol Titration Guidelines for IV insulin therapy?

Updated: Nov 06, 2018
  • Author: Guy W Soo Hoo, MD, MPH; Chief Editor: George T Griffing, MD  more...
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The Portland Protocol Titration Guidelines© are listed below. Insulin infusion may be titrated between 0-30 U/H using these guidelines to rapidly (within 3 h) achieve and maintain blood glucose in the target range (125-175 mg/dL). Round insulin infusion to the nearest tenth of a unit (0.1 U) when necessary.

If blood glucose level is less than 40 mg/dL or more than 450 mg/dL, obtain confirmatory laboratory blood glucose level.

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