Which medications in the drug class Estrogens/Progestins are used in the treatment of Osler-Weber-Rendu Disease (Hereditary Hemorrhagic Telangiectasia)?

Updated: Oct 06, 2020
  • Author: Klaus-Dieter Lessnau, MD, FCCP; Chief Editor: Vincent Lopez Rowe, MD  more...
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Answer

Estrogens/Progestins

Oral contraceptives may be used to reduce bleeding. Topical preparations may be used to help strengthen the mucosa and decrease the susceptibility of the mucosa to external trauma. Before use, screening tests for pulmonary arteriovenous malformations (AVMs) should be performed because of the risk of complications involving thromboembolism.

Estrogen therapy may also be beneficial in some women with HHT and may be used to decrease the amount of bleeding. Oral contraceptives have been shown to be more effective than estrogen alone in mucosal bleeding.

Norethindrone acetate and ethinyl estradiol (Junel 1.5/30, Microgestin 1.5/30, Loestrin 21 1.5/30)

Norethindrone acetate−ethinyl estradiol is used to decrease mucosal bleeding. It probably works by strengthening mucosal tissues and thereby making them more resistant to trauma.

Estradiol (Estrace, Climara, Femring, Elestrin, Alora, Minivelle, Vivelle-Dot)

Estradiol increases synthesis of DNA, RNA, and many proteins in target tissues. Norethindrone acetate−ethinyl estradiol is an option.


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