What is the global prevalence of Osler-Weber-Rendu disease (OWRD) (hereditary hemorrhagic telangiectasia [HHT])?

Updated: Oct 06, 2020
  • Author: Klaus-Dieter Lessnau, MD, FCCP; Chief Editor: Vincent Lopez Rowe, MD  more...
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Answer

The worldwide prevalence is 1 case per 5000-10,000 population In Europe and Japan, the frequency is estimated to be between 1 in 5000 to 8000 people. [4, 14, 32, 33] The prevalence of HHT in a Danish population increased from 13.8 cases per 100,000 population in 1974 to 15.6 cases per 100,000 population in 1995. [34]

The frequency may vary considerably between populations. The highest rates are seen in parts of the Dutch Antilles among the Afro-Caribbean population, with a prevalence of between 1 case per 200 persons and 1 per 1331 persons in the Curaçao and Bonaire regions. [35, 36] In the French department of Ain, the prevalence is 1 case per 2351 persons; in France overall, it is 1 per 8345. [6] Other examples include the Danish island of Funen (1 per 3500) and northern England (1 per 39,216). [37, 7]


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