What is isoimmune neonatal neutropenia?

Updated: May 20, 2021
  • Author: Carly DeFaria, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In isoimmune neonatal neutropenia, the mother produces IgG antineutrophil antibodies to fetal neutrophil antigens that are recognized as nonself. This occurs in 3% of live births. The disorder manifests as neonatal fever, urinary tract infection, cellulitis, pneumonia, and sepsis. The duration of the neutropenia is typically 7 weeks.


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