Which medications in the drug class Bisphosphonates are used in the treatment of Multiple Myeloma?

Updated: Jan 13, 2023
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Bisphosphonates inhibit bone resorption via action on osteoclasts or osteoclast precursors.

Pamidronate (Aredia)

Pamidronate inhibits normal and abnormal bone resorption. It appears to inhibit bone resorption without inhibiting bone formation and mineralization. The optimal timing and duration of therapy are being studied. Pamidronate is administered intravenously (IV) over 2 hours. Newer drugs similar in structure and function are being studied and may have improved efficacy and greater convenience.

Zoledronic acid (Zometa)

Zoledronic acid inhibits bone resorption, possibly by acting on osteoclasts or osteoclast precursors. It is effective in treating the hypercalcemia of malignancy.

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