What are the National Comprehensive Cancer Network (NCCN) criteria for a diagnosis of active multiple myeloma (MM)?

Updated: Mar 06, 2020
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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In the NCCN guidelines, active multiple myeloma is no longer diagnosed using the CRAB criteria (hyperCalcemia, Renal failure, Anemia, Bone lesions) for end-organ damage. The current diagnostic criteria for symptomatic multiple myeloma are as follows [2] :

  • Clonal bone marrow plasma cells ≥10% or bony or extramedullary plasmacytoma (confirmed by biopsy)
  • One or more myeloma-defining events.

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