What are the National Comprehensive Cancer Network (NCCN) criteria for a diagnosis of smoldering multiple myeloma (MM)?

Updated: Mar 06, 2020
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Multiple myeloma is defined as smoldering (asymptomatic) or active (symptomatic). The NCCN criteria for smoldering multiple myeloma are as follows [2] :

  • Serum monoclonal protein ≥3 g/dL,  or
  •  Bence Jones protein ≥500 mg/24 h  and/or
  • Clonal bone marrow plasma cells 10%–59%  and
  • Absence of myeloma-defining events or amyloidosis

The NCCN also recommends that a patient whose bone survey is negative be assessed for bone disease with whole-body skeletal MRI, FDG PET/CT, of low-dose CT to differentiate active from smoldering MM. [2]


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