What are the National Comprehensive Cancer Network (NCCN) criteria for a diagnosis of smoldering multiple myeloma (MM)?

Updated: Sep 30, 2019
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print

Multiple myeloma is defined as smoldering (asymptomatic) or active (symptomatic). The NCCN criteria for smoldering multiple myeloma are as follows [2] :

  • Serum monoclonal protein: IgG or IgA ≥3 g/dL,  or
  •  Bence Jones protein ≥500 mg/24 h  and/or
  • Clonal bone marrow plasma cells 10%–60%  and
  • Absence of myeloma-defining events or amyloidosis

The NCCN also recommends that a patient whose bone survey is negative be assessed for bone disease with whole-body or skeletal MRI, with contrast, or whole-body PET/CT to differentiate active from smoldering MM. [2]

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!