What are the National Comprehensive Cancer Network (NCCN) criteria for a diagnosis of smoldering multiple myeloma (MM)?

Updated: May 11, 2021
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print

Multiple myeloma is defined as smoldering (asymptomatic) or active (symptomatic). The International Myeloma Working Group criteria for smoldering multiple myeloma are as follows [131] :

  • Serum monoclonal protein ≥3 g/dL  or  urinary monoclonal protein (Bence Jones protein) ≥500 mg/24 h  and/or clonal bone marrow plasma cells 10%–60%
  • Absence of myeloma-defining events or amyloidosis

The NCCN also recommends that a patient whose bone survey is negative be assessed for bone disease with whole-body skeletal MRI, FDG PET/CT, or low-dose CT to differentiate active from smoldering MM. [2]

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!