What is the role of combined thalidomide and lenalidomide (Revlimid) in the treatment of multiple myeloma (MM)?

Updated: Sep 30, 2019
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

An analogue of thalidomide, lenalidomide (Revlimid) is now a standard component of MM therapy. In July 2013, Celgene Corp announced that a phase III trial of lenalidomide (Revlimid) met the main goal of improving progression-free survival in patients with newly diagnosed MM. [46] The drug was already approved for use in previously-treated MM, mantle cell lymphoma, and transfusion-dependent anemia caused by myelodysplastic syndromes.

In the late-stage study, treatment with lenalidomide combined with dexamethasone in patients with newly diagnosed MM resulted in significantly longer survival without the cancer worsening, than did treatment with a regimen consisting of melphalan, prednisone, and thalidomide (MPT). [46]


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