What is the international staging system for multiple myeloma (MM)?

Updated: Mar 06, 2020
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
  • Print
Answer

The International Staging System of the International Myeloma Working Group is also based on three stages.

Stage I consists of the following:

  • Beta-2 microglobulin ≤3.5 g/dL and albumin ≥3.5 g/dL
  • CRP ≥4.0 mg/dL
  • Plasma cell labeling index < 1%
  • Absence of chromosome 13 deletion
  • Low serum IL-6 receptor
  • Long duration of initial plateau phase

Stage II consists of the following:

  • Beta-2 microglobulin level ≥3.5 to < 5.5 g/dL,  or
  • Beta-2 microglobulin < 3.5 g/dL and albumin < 3.5 g/dL

Stage III consists of the following:

  • Beta-2 microglobulin of 5.5 g/dL or more

Median survival is as follows:

  • Stage I, 62 months
  • Stage II, 44 months
  • Stage III, 29 months

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!