Which blood studies are performed in the workup of multiple myeloma (MM)?

Updated: May 11, 2021
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Perform a complete blood count (CBC) to determine if the patient has anemia, thrombocytopenia, or leukopenia. The CBC and differential may show pancytopenia. The reticulocyte count is typically low. Peripheral blood smears may show rouleau formation.

The erythrocyte sedimentation rate (ESR) is typically increased. Coagulation studies may yield abnormal results.

Obtain a comprehensive metabolic panel to assess levels of the following:

  • Total protein, albumin, and globulin
  • Blood urea nitrogen (BUN) and creatinine
  • Uric acid (will be elevated if the patient has high cell turnover or is dehydrated)

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