How is monoclonal gammopathy of undetermined significance (MGUS) defined?

Updated: Jul 15, 2019
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Monoclonal gammopathy of undetermined significance (MGUS) is defined by the presence of three criteria:

  • Serum monoclonal M protein (M-protein) concentration < 3 g/dL
  • Bone marrow plasma cell concentration < 10%
  • No evidence of end organ damage

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