What is the NCCN recommended primary induction therapy for patients with multiple myeloma (MM) who are candidates for transplantation?

Updated: Sep 30, 2019
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

For primary induction therapy in patients with MM who are candidates for transplantation, NCCN guidelines recommend the following combinations as preferred regimens [2] :

  • Bortezomib/lenalidomide/dexamethasone (category 1)
  • Bortezomib/cyclophosphamide/dexamethasone (preferred initial treatment in patients with acute renal insufficiency)

Other recommended regimens, according to the NCCN, are as follows:

  • Bortezomib/doxorubicin/dexamethasone (category 1)
  • Carfilzomib/lenalidomide/dexamethasone
  • Ixazomib/lenalidomide/dexamethasone (category 2B)

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