What are the treatment options for multiple myeloma (MM)?

Updated: May 11, 2021
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Treatment choices are guided by the results of the diagnostic workup, which determine the initial classification of the patient's illness into one of the following disorders in the spectrum of MM:

Radiation therapy is the primary therapy for solitary plasmacytoma with or without marrow involvement. Surgery may be required if the lesion causes structural instability or neurologic compromise. [2]

Active surveillance or watchful waiting is recommended for patient with SMM or asymptomatic MM. However, patients at high risk of progression to active MM may benefit from early intervention.

Newly diagnosed patients with MM should be referred to a hematopoietic cell transplant (HCT) center to assess whether they are eligible for HCT and/or high-dose therapy. Transplant-eligible patients are initially treated with primary therapy (induction) followed by high-dose chemotherapy with autologous HCT. [3, 4, 5]

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