Which routine lab tests are performed in the workup of multiple myeloma (MM)?

Updated: Sep 30, 2019
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Routine laboratory tests include the following:

  • Complete blood count and differential
  • Erythrocyte sedimentation rate
  • Comprehensive metabolic panel (eg, levels of total protein, albumin and globulin, BUN, creatinine, uric acid)
  • 24-hour urine collection for quantification of the Bence Jones protein (ie, lambda light chains), protein, and creatinine clearance; proteinuria greater than 1 g/24 hr is a major criterion
  • C-reactive protein
  • Serum viscosity in patients with CNS symptoms, nosebleeds, or very high M protein levels

National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) for del 13, del 17p13, t(4;14), t(11;14), 1q21 amplification as part of the initial diagnostic workup. [2]


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