What are the physical findings of multiple myeloma (MM) with amyloidosis?

Updated: May 11, 2021
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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In patients with MM and amyloidosis, the characteristic examination findings include the following:

  • Shoulder pad sign
  • Macroglossia
  • Typical skin lesions
  • Post-proctoscopic peripalpebral purpura (eyelid purpura may also follow coughing, vomiting, the Valsalva maneuver, or forced expiration during spirometric testing)
  • Carpal tunnel syndrome
  • Subcutaneous nodules

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