Which medications in the drug class CAR T-Cell Therapies are used in the treatment of Multiple Myeloma?

Updated: May 11, 2021
  • Author: Dhaval Shah, MD; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

CAR T-Cell Therapies

Idecabtagene vicleucel (Abecma)

B-cell maturation antigen (BCMA)-directed genetically modified autologous CAR T-cell therapy is indicated for relapsed or refractory MM after ≥4 prior lines of therapy, including an immunomodulatory agent, a proteasome inhibitor, and an anti-CD38 monoclonal antibody. Each idecabtagene vicleucel dose is customized using a patient’s own T-cells to help fight the myeloma. These T-cells are collected and genetically modified to include a new gene that facilitates targeting and killing myeloma cells. Once modified, the cells are infused back into the patient. 


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