What are the diagnostic criteria for monoclonal gammopathy of undetermined significance (MGUS)?

Updated: Sep 07, 2018
  • Author: Suzanne R Fanning, DO; Chief Editor: Emmanuel C Besa, MD  more...
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Monoclonal gammopathy of undetermined significance (MGUS) must be differentiated from multiple myeloma (MM) and smoldering MM (SMM). Criteria for MGUS established by the International Myeloma Working Group [29] and the World Health Organization [30] are as follows:

  • Serum M-protein level < 3 g/dL
  • Bone marrow plasma cells < 10% and low level of plasma cell infiltration in a trephine biopsy specimen
  • No evidence of B-cell proliferative disorder (ie, MM, Waldenström macroglobulinemia, amyloid light-chain amyloidosis)
  • No M-protein or only small amounts of monoclonal light chain in urine
  • No osteolytic lesions, anemia, hypercalcemia, or M-protein–related renal function impairment

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