What is the risk of infection in patients with monoclonal gammopathy of undetermined significance (MGUS)?

Updated: Sep 07, 2018
  • Author: Suzanne R Fanning, DO; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Kristinsson et al reported that patients with MGUS had a 2-fold increased risk (P < 0.05) of developing any infection. [27] The risk extended to both bacterial and viral infections, and the following specific infections were noted:

  • Pneumonia
  • Osteomyelitis
  • Septicemia
  • Pyelonephritis
  • Cellulitis
  • Endocarditis
  • Meningitis
  • Influenza
  • Herpes zoster

Infection risk was highest in patients with M-protein concentrations over 2.5 g/dL, but was also increased in those with concentrations below 0.5 g/dL. Patients with MGUS who developed infections had no excess risk of progression to related malignancy.


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