Which factors are associated with the progression of monoclonal gammopathy of undetermined significance (MGUS) to myeloid malignancy?

Updated: Sep 07, 2018
  • Author: Suzanne R Fanning, DO; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

In a study of 728 Swedish MGUS patients followed for up to 30 years, 84 patients developed a lymphoid disorder, representing a cumulative risk of 15.4%. The 30-year cumulative risk for myeloid malignancies was less than 2%. The 30-year cumulative risk for MM, which occurred in 53 patients, was 10.6%, with an approximately 0.5% annual risk. The following factors were significantly associated with progression [22] :

  • An abnormal FLC ratio of less than 0.26 or more than 1.65

  • An M-protein concentration of 1.5 g/dL or more

  • Reduction of one or two noninvolved immunoglobulin isotype levels


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