What are protease inhibitor-based antiretroviral therapy (ART) regimens for pregnant women with HIV infection?

Updated: Jun 23, 2020
  • Author: Madhu Chhanda Choudhary, MD; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Answer

Regimens include the following:

  • Atazanavir (ATV) is recommended to be combined with low-dose ritonavir (RTV): ATV 300 mg plus  RTV 100 mg PO daily as a single daily dose; some experts increase ATV/RTV dose to 400/100 mg daily during second and third trimester; manufacturer recommends dose increase in pregnancy if combined with tenofovir or H2 blocker in treatment-experienced patients and with efavirenz in treatment-naive patients [8] or
  • Darunavir (DRV) 600 mg combined with 100 mg RTV twice daily [9] : Once-daily dosing achieves low darunavir trough in pregnancy and should not be used, especially in treatment-experienced patients.

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