Which medications in the drug class Histamine H2 Antagonists are used in the treatment of Methemoglobinemia?

Updated: Dec 09, 2018
  • Author: Mary Denshaw-Burke, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Histamine H2 Antagonists

Cytochrome P-450 inhibitors are recommended only for patients with methemoglobinemia secondary to dapsone.

Cimetidine (Tagamet HB 200)

Cimetidine inhibits conversion of dapsone to its oxidizing metabolite, dapsone hydroxylamine, by the P-450 system, thereby preventing further development of dapsone-induced methemoglobinemia.

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