How does the prevalence of methemoglobinemia vary by sex?

Updated: Dec 09, 2018
  • Author: Mary Denshaw-Burke, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

The inheritance pattern of the congenital enzyme deficiency form of the disease is autosomal recessive. Hb M is inherited in an autosomal dominant pattern. There is no association between sex and the frequency of congenital methemoglobinemia. However, because G6PD deficiency is X-linked, there is a higher risk of acquired methemoglobinemia in males with G6PD deficiency when they are subjected to oxidative stress. Otherwise, no difference exists between males and females with respect to the incidence of acquired methemoglobinemia.


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