What is the role of rasburicase therapy in the etiology of methemoglobinemia?

Updated: Dec 21, 2020
  • Author: Mary Denshaw-Burke, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Rasburicase treatment for tumor lysis syndrome in patients with low catalase activity (inherited or acquired) may result in methemoglobinemia secondary to the formation of hydrogen peroxide. [33, 34, 35] Some authors have suggested that catalase activity be measured before rasburicase therapy is initiated in this setting.


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