Which history findings are characteristic of methemoglobinemia?

Updated: Dec 09, 2018
  • Author: Mary Denshaw-Burke, MD, FACP; Chief Editor: Emmanuel C Besa, MD  more...
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Answer

Key elements of the history include the following:

  • In congenital methemoglobinemia, characteristic diffuse persistent slate-gray cyanosis, often present from birth; patients are often asymptomatic despite the presence of cyanosis
  • In acute methemoglobinemia, which is usually acquired, a history of exposure to methemoglobinemia-inducing substances (not always available)
  • Any known family history of methemoglobinemia or glucose-6-phosphate dehydrogenase (G6PD) deficiency

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