How is maraviroc (MVC) administered in antiretroviral therapy for HIV infection in adolescents and young adults?

Updated: Mar 16, 2020
  • Author: David J Cennimo, MD, FAAP, FACP, AAHIVS; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Answer

Maraviroc (MVC)

Indicated in combination with other antiretrovirals for the treatment of only CCR5-tropic HIV-1 infection in patients aged ≥2 years who weigh at least 10 kg

It is imperative to test all patients for CCR5 tropism using a highly sensitive tropism assay before initiating the drug

Outgrowth of pre-existing low-level CXCR4- or dual/mixed-tropic HIV-1 not detected by tropism testing at screening has been associated with virologic failure on maraviroc

Dosing for patients older than 16 years

  • When given with potent CYP3A inhibitors (with or without CYP3A inducers), including protease inhibitors (except TPV/RTV): 150 mg PO BID
  • When given with nucleoside reverse transcriptase inhibitors, ENF, TPV/RTV, NVP, raltegravir (RAL), and drugs that are not potent CYP3A inhibitors or inducers: 300 mg PO BID
  • When given with potent CYP3A inducers, including EFV and ETR (without a strong CYP3A inhibitor): 600 mg PO BID
  • Additional dose adjustment required with renal impairment

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