How is lopinavir/ritonavir (LPV/RTV) administered in antiretroviral therapy for HIV infection in adolescents and young adults?

Updated: Mar 16, 2020
  • Author: David J Cennimo, MD, FAAP, FACP, AAHIVS; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Answer

Answer

Lopinavir/ritonavir (LPV/RTV)

  • LPV 400 mg/RTV 100 mg per dose BID (adolescent, ≥40 kg)
  • Pediatric dose (>6 mo - 18 years): For individuals receiving concomitant nelfinavir (NFV), NVP, EFV, or FPV (these drugs induce LPV metabolism and reduce LPV plasma levels), increased LPV/RTV dosing is required with concomitant administration of these drugs and/or in treatment-experienced patients in whom reduced susceptibility to LPV is suspected (such as those with prior treatment with other protease inhibitors)
  • Once-daily dosing is not recommended in adolescents

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