How is atazanavir (ATV) administered in antiretroviral therapy for HIV infection in adolescents and young adults?

Updated: Mar 16, 2020
  • Author: David J Cennimo, MD, FAAP, FACP, AAHIVS; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Answer

Answer

The definition of "adolescent" may differ depending on the regimen; for regimens with specific definitions of "adolescent," the definition is provided in parentheses following the regimen.

Atazanavir (ATV)

  • Age 16-21 years: For antiretroviral-naive patients, give ATV 300 mg PO plus ritonavir (RTV) 100 mg PO with food or ATV 400 mg PO once daily with food [11]
  • Antiretroviral-experienced patients: ATV 300 mg PO plus RTV 100 mg PO, both once daily with food
  • Dosing recommendations during coadministration with other antiretrovirals: ATV in combination with EFV in therapy-naive patients only (adult dose): ATV 400 mg plus RTV 100 mg PO plus EFV 600 mg PO, all once daily but at separate times (ATV + RTV with food, EFV without food)
  • ATV in combination with TDF (adult dose): ATV 300 mg PO plus RTV 100 mg PO plus TDF 300m g PO, all once daily with food
  • Only RTV-boosted ATV should be used in combination with TDF, because TDF decreases ATV exposure

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