How is tenofovir disoproxil fumarate (TDF) administered in antiretroviral therapy for HIV infection in adolescents and young adults?

Updated: Mar 16, 2020
  • Author: David J Cennimo, MD, FAAP, FACP, AAHIVS; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Answer

Answer

Tenofovir DF (TDF)

  • 300 mg PO once daily (adolescent, ≥12 years and ≥35 kg)
  • Truvada: Combination formulation including FTC 200 mg/TDF 300 mg; 1 tablet PO once daily (≥35 kg)
  • Although TDF is approved for age >2 years, data pointing to decreased bone mineral density have led to the recommendation to reserve use until later adolescence (Tanner stage 4 or 5) [6]
  • Pediatric dosing of Truvada (≥17 kg) is as follows:
    • 17 to < 22 kg: One 100 mg/150 mg tablet PO daily
    • 22 to < 28 kg: One 133 mg/200 mg tablet PO daily
    • 28 to < 35 kg: One 167 mg/250 mg tablet PO daily
    • ≥35 kg: One 200 mg/300 mg tablet PO daily
  • Cimduo: Combination formulation including 3TC 300 mg/TDF 300 mg; 1 tablet PO once daily (adolescent, ≥35 kg)

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