How is lamivudine (3TC) administered in antiretroviral therapy for HIV infection in adolescents and young adults?

Updated: Mar 16, 2020
  • Author: David J Cennimo, MD, FAAP, FACP, AAHIVS; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Answer

Answer

Lamivudine (3TC)

  • If ≥50 kg, give 150 mg PO BID or 300 mg PO once daily; if < 50 kg, give 4 mg/kg (up to 150 mg) BID (adolescent, ≥16 years)
  • Combivir: Combination formulation including 3TC 150 mg/ZDV 300 mg; give 1 tablet PO BID (adolescent, ≥30 kg)
  • Trizivir: Combination formulation including ABC 300 mg/3TC 150 mg/ZDV 300 mg; give 1 tablet PO BID (adolescent, ≥ 40 kg)
  • Epzicom: Combination formulation including ABC 600 mg/3TC 300 mg; give 1 tablet PO once daily (adolescent, ≥40 kg)
  • Cimduo: Combination formulation including 3TC 300 mg/TDF 300 mg; 1 tablet PO once daily (adolescent, ≥35 kg)

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