How is abacavir (ABC) administered in antiretroviral therapy for HIV infection in adolescents and young adults?

Updated: Mar 16, 2020
  • Author: David J Cennimo, MD, FAAP, FACP, AAHIVS; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Answer

Answer

The definition of "adolescent" may differ depending on the regimen; for regimens with specific definitions of "adolescent," the definition is provided in parentheses following the regimen.

Abacavir (ABC)

Patients must be tested for HLA-B*5701 prior to initiation. Patients who are positive are at the highest risk of abacavir hypersensitivity. [1]

  • ABC 300 mg PO BID or 600 mg PO once daily (adolescent, ≥16 years); liquid formulation available at 20 mg/mL with the same recommended dose
  • Trizivir: Combination formulation including ABC 300 mg/lamivudine (3TC) 150 mg/zidovudine (ZDV) 300 mg; give 1 tablet PO BID (adolescent, ≥40 kg); not a first-line therapy
  • Epzicom: Combination formulation including ABC 600 mg/3TC 300 mg; give 1 tablet PO once daily (adolescent, >16 years)

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