How does colchicine and protease inhibitors (PIs) interact?

Updated: Jan 15, 2019
  • Author: Jason F Okulicz, MD, FACP, FIDSA; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Answer

Answer

Do not coadminister colchicine and PIs in patients with hepatic or renal impairment.

In combination with PIs for treatment of gout flares, administer colchicine 0.6 mg for 1 dose, followed by 0.3 mg 1 hours later (do not repeat dose for at least 3 days); with FPV without RTV, give 1.2 mg for 1 dose and do not repeat dose for at least 3 days.

In combination with PIs for prophylaxis of gout flares, administer colchicine 0.3 mg once daily or every other day; with FPV without RTV, use colchicine 0.3 mg BID, 0.6 mg once daily, or 0.3 mg once daily.

For treatment of familial Mediterranean fever, do not exceed colchicine 0.6 mg once daily or 0.3 mg BID; with FPV without RTV, do not exceed 1.2 mg once daily or 0.6 mg BID.


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