How do antacids and protease inhibitors (PIs) interact?

Updated: Jan 15, 2019
  • Author: Jason F Okulicz, MD, FACP, FIDSA; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Answer

Answer

Antacids can potentially decrease the drug concentrations of PIs.

ATV should be given at least 2 hours before or 1 hour after antacids or buffered medications.

FPV should be given simultaneously with, or at least 2 hours before or 1 hour after, antacids.

TPV should be given at least 2 hours before or 1 hour after antacids.


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