How do antipsychotics and protease inhibitors (PIs) interact?

Updated: Jan 15, 2019
  • Author: Jason F Okulicz, MD, FACP, FIDSA; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Answer

Answer

Coadministration of quetiapine with PIs is expected to increase quetiapine AUC; in patients receiving a PI, start quetiapine at the lowest dose, titrate up as needed, and monitor for adverse effects of quetiapine; in patients initiating a PI while on a stable dose of quetiapine, reduce quetiapine to one sixth of the original dose and closely monitor for quetiapine effectiveness and adverse effects


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