Which factors are used to individualize antiretroviral therapy (ART) for HIV infection?

Updated: Oct 21, 2019
  • Author: Sowmya Nanjappa, MD; Chief Editor: John Bartlett, MD  more...
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Answer

Answer

Therapy should be individualized and based on factors such as the following:

  • Comorbid conditions (eg, cardiovascular disease, chemical dependency, liver disease, psychiatric disease, renal diseases, tuberculosis)
  • Potential adverse drug effects
  • Potential drug interactions with other medications
  • Pregnancy or pregnancy potential
  • Results of genotypic drug-resistance testing
  • Gender and pretreatment CD4 count if considering nevirapine (NVP)
  • HLA-B*5701 testing if considering abacavir (ABC)
  • Coreceptor tropism assay if considering maraviroc (MVC)
  • Patient adherence potential
  • Convenience (eg, pill burden, dosing frequency, food and fluid considerations)

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