How are coexisting HIV and HCV infections treated?

Updated: May 07, 2020
  • Author: Shirin A Mazumder, MD, FIDSA; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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It is important to monitor alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels at 1 month and then every 3 months after the initiation of ART.

ART should be started in persons co-infected with HCV and HIV in accordance with the recommendations for initiating ART in treatment-naive patients. [21, 22, 23] ART should be started at least 4-6 weeks before hepatitis C treatment is initiated.

The objective of HCV antiviral treatment is to cure the HCV infection, reflected by a sustained virologic response. Although patients with HIV and HCV coinfection traditionally had lower response rates to HCV treatment with older regimen of ribavirin and peginterferon compared to individuals without HIV infection, patients with coinfection appear to have comparable sustained virologic response rates with all oral, direct-acting antiviral (DAA) combination therapy.

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