What is included in the initial evaluation of coexisting HIV and HCV infections?

Updated: May 07, 2020
  • Author: Shirin A Mazumder, MD, FIDSA; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Answer

Answer

Prior to initiating ART, screen patients with HIV infection for HCV using sensitive immunoassays licensed for the detection of antibody to HCV in blood; to confirm the presence of chronic infection, persons who are HCV seropositive should be tested for HCV ribonucleic acid (RNA) using a qualitative or quantitative assay. [20]

Advise patients with HCV/HIV to avoid alcohol and receive HAV and HBV vaccines, if screened negative via serology. [6]

Drug-induced liver injury (DILI) following ART is more common in HIV/HCV coinfection; eradication of HCV infection may decrease the likelihood of antiretrovirus-associated DILI. [6]


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