How does hepatitis B (HBV) infection affect the course of HIV infection?

Updated: May 07, 2020
  • Author: Shirin A Mazumder, MD, FIDSA; Chief Editor: Michelle R Salvaggio, MD, FACP  more...
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Patients with HIV infection are at a greater risk for hepatitis B virus (HBV) infection, due to the common route of transmission.

Patients with HIV infection are at a higher risk for developing cirrhosis, hepatic decompensation, and hepatocellular carcinoma than patients diagnosed with only chronic HBV infection. [6, 7]

Treatment of HIV infection may improve the virological, histological, and clinical evolution of chronic HBV infection. [8]

Several antiretroviral agents, such as emtricitabine, lamivudine, and tenofovir, have activity against HIV and HBV, while others, such as entecavir, have limited activity against HIV but lead to the development of HIV-resistant strains if used alone. [9]

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