What are the pharmacokinetic interactions that affect drug absorption in antiretroviral therapy?

Updated: Jul 12, 2021
  • Author: Shahab Qureshi, MD, FACP; Chief Editor: Michael Stuart Bronze, MD  more...
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Answer

Answer

Pharmacokinetic interactions that affect drug absorption include the following:

  • Acid-reducing agents
  • Products that contain polyvalent cations can bind to integrase strand transfer inhibitors (INSTIs) and reduce absorption
  • Drugs that induce or inhibit the enzyme CYP3A4 or efflux transporter P-glycoprotein [P-gp] in the intestines

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